Vemurafenib (V) in BRAF V600E metastatic melanoma (mM): Analysis of 507 patients (pts) enrolled in the French temporary authorization for use (ATU). This is an ASCO Meeting Abstract from the 2012 ASCO ...

High Frequency of Submicroscopic Hemizygous Deletion Is a Major Mechanism of Loss of Expression of PTEN in Uveal Melanoma Skin biopsy samples of 31 patients with a PCLBCL classified as either primary ...

The Cytogenetics Laboratory performs chromosome analysis, fluorescence in situ hybridization (FISH), and array comparative genomic hybridization (array CGH) on cells prepared from a wide variety of ...

Comparative genomic hybridization (CGH) was developed to identify pathogenic DNA copy-number changes (e.g., duplications, deletions) on a genome-wide scale, and to map these changes to genomic ...

Santhosh Girirajan is the T. Ming Chu Professor of Biochemistry and Molecular Biology and Professor of Genomics at Penn State. The Girirajan Laboratory is interested in untangling the genetic and ...

Using SNP-CGH to Profile for Amplifications, Duplications, and Deletions The beginnings of personalized medicine have been forged by recent advances in SNP genotyping technologies. It is now possible ...

Polyploid genomes, formed through repeated whole-genome duplication and hybridization, underpin the evolution of many important crops, yet their internal structure often remains unresolved when ...

A new study presents genomic evidence of hybridization between two closely related species of sea stars -- Asterias rubens, the common starfish, and Asterias forbesi, known as Forbes' sea star.