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Genentech's Giredestrant: First Oral SERD for Breast Cancer Survival
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Let’s talk about lidERA trial which was presented at SABCS! This study tested whether the oral SERD (selective estrogen receptor degrader), giredestrant, is superior to current endocrine therapy as adjuvant therapy in ER /HER2 negative early stage breast cancer. Giredestrant binds to the estrogen receptor and induces a change in it that not only blocks the estrogen receptor but breaks it down as well. SERDs are approved in metastatic breast cancer but this is the first study in early stage breas
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A major update from SABCS: BCRF investigator Dr. Aditya Bardia shares encouraging results from the lidERA trial, studying a new hormone therapy called giredestrant for early HR breast cancer. In the trial, giredestrant lowered the risk of cancer coming back and showed fewer treatment-related side effects, meaning it may be both more effective and easier to stay on than current options. If approved, it could become the first new adjuvant endocrine therapy in decades. FDA review is expected in 202
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Replying to @Vicky 🎥 Can you switch from anastrozole to giredestrant? So many of you asked this — especially those in surgical menopause currently taking aromatase inhibitors like anastrozole. Here’s what we know so far ⬇️ 🧬 Giredestrant is a new oral SERD (Selective Estrogen Receptor Degrader) that’s being studied as initial adjuvant therapy — meaning it was started shortly after surgery, not as a switch from anastrozole. As of now, there’s no trial data on whether it’s safe or effective to s
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